Prison Break 4 The fourth, and final season of the serial drama television series Prison Break commenced airing in the United States on September 1, 2008. It consists of 24 episodes (22 television episodes and 2 straight to DVD episodes), 16 of which aired from September 2008 to December 2008. The television series resumed on April 17, 2009 and concluded on May 15, 2009 with a two episode finale.